Evidence supporting the use of: Glycyrrhizinic acid
For the health condition: Cough (spastic)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhizinic acid, a principal component of licorice root (Glycyrrhiza glabra), has been used in traditional medicine systems—such as Traditional Chinese Medicine (TCM) and Ayurveda—for its expectorant and demulcent properties to soothe the throat and alleviate coughs, including spastic (dry or persistent) coughs. In TCM, licorice is often included in cough remedies to "harmonize" herbal formulas and to reduce throat irritation. Historical texts describe its use for relieving coughs, sore throats, and bronchial irritation.

On the scientific front, glycyrrhizinic acid has demonstrated anti-inflammatory, antiviral, and immunomodulatory effects in vitro and in some animal studies. Some research suggests it may inhibit the replication of certain respiratory viruses and reduce airway inflammation. However, direct clinical evidence supporting its effectiveness specifically for spastic cough is limited. Most modern clinical studies are small-scale, not focused specifically on cough, or use licorice extract rather than isolated glycyrrhizinic acid. Thus, while there is a historical tradition for its use in cough (including spastic types), robust scientific validation through large-scale, high-quality clinical trials is lacking.

Potential side effects, such as hypertension and hypokalemia with excessive or prolonged use, should be considered. In summary, the use of glycyrrhizinic acid for spastic cough is largely based on traditional practices, with limited scientific evidence specifically supporting its application for this condition.

More about Glycyrrhizinic acid
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