Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Glycyrrhiza, commonly known as licorice root, has a long history of use in traditional medicine systems, such as Traditional Chinese Medicine (TCM) and Ayurveda, for treating respiratory conditions including coughs, particularly those described as "spastic" or spasmodic. In TCM, Glycyrrhiza is considered to "harmonize" other herbs in a formula and to "moisten the lungs," helping to alleviate cough and soothe sore throats. Its demulcent and expectorant properties are thought to help reduce irritation in the airways and suppress coughing.

Modern pharmacological studies suggest that Glycyrrhiza contains compounds like glycyrrhizin, which exhibit anti-inflammatory and soothing effects on the mucous membranes of the respiratory tract. Some in vitro and animal studies have demonstrated antitussive (cough-suppressing) activity. However, robust clinical trials in humans are limited. Most evidence for its use in spastic cough originates from historical and traditional sources rather than from high-quality, large-scale clinical trials. Thus, while there is some scientific rationale and preliminary research supporting its use, the primary justification remains traditional, and the overall quality of evidence is moderate.

It is important to note that long-term or excessive use of Glycyrrhiza can cause side effects such as hypertension and hypokalemia due to its mineralocorticoid effects. Therefore, its use should be monitored, especially in vulnerable populations.

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