Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Flavonoid glycosides are primarily used to support or treat coughs, including spastic coughs, based on traditional use rather than robust scientific evidence. In herbal medicine, flavonoid-rich plants such as Grindelia, Elderflower (Sambucus nigra), and Mullein (Verbascum thapsus) have been used historically as remedies for cough and respiratory complaints. Traditional use is likely based on the observed soothing, anti-inflammatory, and mild antispasmodic effects of these plant preparations. Flavonoid glycosides are thought to contribute to these effects by reducing irritation in the respiratory tract and potentially modulating inflammation. However, while some laboratory studies suggest that flavonoids can exert anti-inflammatory and antioxidant effects, there is limited direct clinical evidence to support their efficacy specifically against spastic cough in humans. The available evidence largely consists of ethnobotanical and historical records, with few rigorous clinical trials. As a result, the use of flavonoid glycosides for spastic cough is best characterized as rooted in traditional practices, with a modest (rated 2/5) evidence base that is not strongly validated by modern scientific research.

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