Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Andrographolide, the main bioactive compound from Andrographis paniculata, has a long history of use in traditional medicine systems such as Ayurveda, Traditional Chinese Medicine, and traditional Thai medicine. It is commonly employed to manage symptoms of upper respiratory tract infections, including coughs—though the term "spastic cough" is not always explicitly used in historical texts. The traditional rationale is based on its described "cooling" and "detoxicating" properties, believed to clear heat and relieve throat and respiratory irritation.

Scientifically, several modern studies have evaluated Andrographis extracts (often standardized for andrographolide) for their effects on cough and respiratory symptoms, primarily in the context of common cold and uncomplicated upper respiratory tract infections. While some randomized controlled trials and meta-analyses suggest modest reductions in cough severity and duration compared to placebo, these studies typically address acute, productive, or dry cough associated with infections—not specifically "spastic" (i.e., paroxysmal or pertussive) cough.

Overall, while there is a traditional basis for using andrographolide-containing herbs for coughs, and some scientific evidence supports benefit in general cough associated with infections, robust evidence for its effectiveness specifically against "spastic" cough is lacking. The evidence quality is moderate for general cough relief, warranting a score of 2. More rigorous, targeted research is needed to confirm efficacy for spastic cough.

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