Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Stephania root (commonly referring to Stephania tetrandra or related species) has been used in traditional Chinese medicine (TCM) and other herbal systems primarily for its anti-inflammatory and analgesic properties. In traditional formulations, Stephania root is sometimes included in herbal blends aimed at treating symptoms such as cough, especially when cough is thought to result from "wind-heat" or "phlegm" disorders in TCM theory. The root is considered to have antitussive and expectorant effects according to some traditional texts, although it is not a leading herb for cough compared to others like Platycodon grandiflorus or Glycyrrhiza uralensis.

There is limited scientific research specifically validating Stephania root’s effectiveness for cough. Most available studies have focused on its active alkaloids (e.g., tetrandrine) for anti-inflammatory, immunomodulatory, or antihypertensive effects. Animal studies and in vitro research suggest some potential for reducing airway inflammation, but direct evidence for its antitussive (cough-suppressing) action in humans is lacking. No high-quality clinical trials have confirmed its efficacy for cough in modern medical literature. Most of the support for its use against cough comes from historical and traditional usage as recorded in TCM pharmacopeias rather than robust scientific validation.

In summary, Stephania root’s use for cough is primarily justified by tradition, and the current evidence base supporting this use is weak, meriting a score of 2 out of 5.

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