Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Atractylone is a major sesquiterpene component found in Atractylodes species, which are widely used in Traditional Chinese Medicine (TCM). In TCM, the herb Atractylodes (particularly Atractylodes macrocephala) is utilized to "dry dampness" and strengthen the spleen. Cough associated with "dampness" is often conceptualized in TCM as a result of impaired fluid transformation and transportation, leading to accumulation of phlegm and dampness in the lungs. Atractylone, as a representative compound of Atractylodes, is thus indirectly implicated in the traditional approach to managing damp-related coughs.

However, the direct scientific evidence specifically supporting atractylone’s efficacy for treating cough—especially cough attributed to "dampness"—is limited. Most modern research on atractylone has focused on its anti-inflammatory, immunomodulatory, and gastrointestinal effects rather than on respiratory conditions. While some studies suggest that Atractylodes extracts may have general anti-inflammatory and anti-allergic properties, there is insufficient clinical data to definitively support its use for cough.

In summary, the use of atractylone for cough (damp) is primarily justified by traditional medical practices, rather than robust scientific validation. The evidence level is modest, reflecting historical use and limited preclinical research, but a lack of targeted clinical trials or mechanistic studies specifically addressing this indication.

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