Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the body system: Cortisol

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Pantothenic acid (vitamin B5) is most commonly discussed in the context of the "Cortisol body system"—typically referring to adrenal health and stress response—based on traditional and theoretical grounds rather than robust scientific validation. Historically, vitamin B5 has been referred to as an "anti-stress" vitamin in popular health literature and among some naturopathic and integrative practitioners. This belief stems from early animal research in the mid-20th century, which noted that pantothenic acid deficiency in rats could lead to impaired adrenal function and reduced synthesis of adrenal hormones, including cortisol. Consequently, pantothenic acid has been marketed as a nutrient that supports adrenal glands and helps manage stress. However, direct human evidence supporting pantothenic acid supplementation for improving cortisol function or managing stress is limited and not well-established in the scientific literature. Most modern clinical studies have not confirmed a significant impact of pantothenic acid supplementation on cortisol levels or adrenal health under typical dietary conditions. The use of pantothenic acid for "supporting the Cortisol body system" is, therefore, primarily rooted in tradition and early animal research rather than strong, high-quality human evidence.

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Other body systems supported by pantothenic acid (vitamin B5)

Adrenal Cortex
Adrenal Glands
Brain
Cortisol
Glandular System
Hair
Mitochondria
Nerves
Skin