Evidence supporting the use of: Holy Basil
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Holy Basil (Ocimum sanctum), also known as Tulsi, has a long history of traditional use in Ayurvedic medicine for stress relief and promoting general well-being. In recent years, scientific interest has focused on its potential adaptogenic properties, particularly its effects on the stress hormone cortisol. Several animal and human studies have explored Holy Basil's ability to modulate the stress response. For example, a randomized, double-blind, placebo-controlled trial published in 2012 found that subjects taking Holy Basil extract reported improved stress symptoms and lower stress scores compared to placebo. Other studies have shown that Holy Basil may help normalize blood cortisol levels and reduce the physiological impacts of stress in both animals and humans. The proposed mechanisms involve modulation of the hypothalamic-pituitary-adrenal (HPA) axis and antioxidant properties that may help buffer the body’s response to stressors.

However, the overall quality and quantity of human clinical trials remains limited. Most studies have small sample sizes and variable methodologies, making it difficult to draw strong conclusions. Nonetheless, the available scientific evidence tentatively supports Holy Basil’s use in supporting healthy cortisol balance and managing mild stress. More rigorous, large-scale human trials are needed to fully validate these effects and clarify optimal dosing and safety profiles.

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Products containing Holy Basil

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