Evidence supporting the use of: Eleutherococcus gracilistylus
For the body system: Cortisol

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Eleutherococcus gracilistylus, a species related to Eleutherococcus senticosus (Siberian ginseng), has a history of use in traditional Chinese medicine. Its roots and stems have been used to enhance vitality, reduce fatigue, and improve resistance to stress—functions that align with the concept of supporting the body’s ability to manage stress, often linked to the hypothalamic-pituitary-adrenal (HPA) axis and cortisol regulation in modern terminology. However, the application of E. gracilistylus specifically for modulating cortisol or directly supporting the “cortisol body system” is based largely on tradition rather than robust scientific evidence. Studies on E. gracilistylus are limited, and while some research on related adaptogenic plants (such as E. senticosus) suggests possible effects on stress response and fatigue mitigation, direct evidence on cortisol modulation is sparse. Traditional texts often describe its use for strengthening “qi” and combating weakness, which may be loosely interpreted as supporting stress adaptation. Few animal or in vitro studies have explored its mechanisms, and clinical studies are lacking. In summary, the use of Eleutherococcus gracilistylus to support the cortisol or stress response system is primarily justified by traditional usage rather than scientific validation. The evidence rating reflects the paucity of direct research and the reliance on historical context and anecdotal reports.

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