Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bovine adrenal glandular extracts are sometimes used in dietary supplements aimed at supporting the body's response to stress, which is often associated with cortisol regulation. The rationale stems from the concept of "glandular therapy," which posits that consuming animal glands can support the corresponding human glands. While this approach has a long tradition in alternative medicine, there is some emerging scientific interest in glandulars, though evidence remains limited and of low quality.

A handful of studies and case reports suggest that bovine adrenal extracts may have minor effects on fatigue and stress resilience, but robust, well-controlled clinical trials are lacking. Most available evidence is anecdotal or derived from animal studies, not large-scale human research. Furthermore, the active components, when taken orally, are likely broken down in the digestive system, casting doubt on their direct efficacy. Regulatory bodies like the FDA have not approved these extracts for cortisol regulation or adrenal support, and mainstream endocrinology does not endorse their use.

In summary, while the use of bovine adrenal extracts for supporting cortisol-related body functions has some historical and limited scientific backing, the overall quality and quantity of the evidence is low, and significant skepticism remains regarding their effectiveness and safety.

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