Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Amino acids have some scientific support for their role in supporting the body’s response to cortisol, the primary stress hormone. Cortisol is produced in the adrenal glands and regulates metabolism, immune response, and the body's stress response. During periods of chronic stress, cortisol levels can become dysregulated, potentially leading to muscle breakdown, fatigue, and other health concerns.

Branched-chain amino acids (BCAAs), such as leucine, isoleucine, and valine, are of particular interest. Research indicates that BCAAs may help reduce exercise-induced increases in cortisol, potentially moderating the catabolic (muscle-breaking) effects of this hormone. Some studies in athletes have shown that BCAA supplementation can blunt the rise in cortisol following intense physical activity, though results are not always consistent. Additionally, amino acids like glutamine have been studied for their potential to modulate immune suppression associated with elevated cortisol during stress or illness, with some modest supportive findings.

However, most evidence supporting the use of amino acids for cortisol regulation is limited to specific contexts—such as athletic performance, recovery, or severe physiological stress. There is little direct evidence that general amino acid supplementation meaningfully alters baseline cortisol levels in healthy adults, nor is it a primary or standalone therapy for chronic stress or adrenal dysfunction. Thus, while there is scientific rationale and some supportive studies, the overall strength of evidence is modest and context-dependent.

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