Evidence supporting the use of: Molybdenum
For the health condition: Copper Toxicity

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Molybdenum is scientifically validated as a supportive treatment for copper toxicity, especially in veterinary medicine and certain rare human disorders. Molybdenum is an essential trace element that acts as a cofactor for several enzymes, including sulfite oxidase, xanthine oxidase, and aldehyde oxidase. Its relevance to copper metabolism centers on its role in forming thiomolybdates in the body, which bind copper and reduce its absorption and bioavailability.

In veterinary practice, particularly in sheep and cattle, molybdenum supplementation is a well-established intervention to prevent and treat copper toxicity. This is because ruminants are especially sensitive to copper imbalances, and molybdenum supplementation (often alongside sulfur) can effectively prevent copper accumulation in the liver by promoting the formation of insoluble copper-molybdenum complexes that are excreted.

In humans, copper toxicity is less common but may occur in conditions like Wilson’s disease or due to environmental/occupational exposure. While primary treatments for Wilson’s disease include chelating agents such as penicillamine and zinc therapy, some studies and case reports suggest that molybdenum compounds (such as ammonium tetrathiomolybdate) can reduce copper absorption and are under investigation as possible therapies. Clinical trials have shown tetrathiomolybdate to be effective in lowering copper levels and as an adjunct in treating Wilson’s disease, particularly when rapid copper reduction is needed or when other therapies are contraindicated.

Overall, the scientific basis for molybdenum’s use in copper toxicity is strong in animals and emerging in human medicine, with ongoing research supporting its efficacy and safety.

More about Molybdenum
More about Copper Toxicity

Other ingredients used for Copper Toxicity

Molybdenum
vitamin C
Zinc

Other health conditions supported by Molybdenum

Copper Toxicity