Evidence supporting the use of: Vitamin C (ascorbic acid)
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbic acid) has a long history of use in convalescence, primarily based on its essential role in immune function, collagen synthesis, and as an antioxidant. Scientific evidence shows that Vitamin C deficiency can impair wound healing and immune responses, which are crucial during recovery from illness or surgery. Supplementation corrects deficiency and supports normal physiological functions required for convalescence. However, clinical trials in well-nourished individuals show limited benefit of high-dose Vitamin C supplementation in expediting recovery from most illnesses, except in cases where deficiency is present or the individual is under significant physiological stress (such as severe infections, trauma, or burns). In these circumstances, some studies suggest that Vitamin C may reduce the length of hospital stay or improve recovery markers, but the effect size is generally modest and evidence quality varies. Major reviews and guidelines do not universally recommend Vitamin C supplementation for all convalescent patients, but acknowledge its importance in individuals at risk of deficiency (e.g., malnourished, elderly, critically ill). Thus, while there is scientific rationale for its use in specific contexts, strong clinical evidence supporting routine use in all convalescent patients is limited.

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