Proline-rich peptides (PRPs), especially those derived from colostrum, have been the subject of scientific investigation for their potential role in supporting convalescence, which refers to the recovery period following illness or medical treatment. PRPs are short chains of amino acids with a high content of the amino acid proline. They have immunomodulatory properties, meaning they can help regulate the immune system. Studies have shown that PRPs can modulate cytokine production, promote the maturation of immune cells, and may help restore immune system balance after periods of stress or illness (Janusz et al., 2007).

Clinical research, though still limited, suggests that supplementation with bovine colostrum (a rich source of PRPs) may enhance recovery by supporting immune function and reducing the incidence or severity of infections in people undergoing intense physical stress or during recovery from illness (Davison et al., 2014). Additionally, PRPs have been shown to cross the blood-brain barrier and exert neuroprotective effects, which might benefit cognitive recovery in convalescent states.

However, most of the studies are preliminary, involve small sample sizes, or are based on animal models. While the mechanism of action is plausible and some human data are available, large-scale, well-controlled clinical trials are still lacking. Thus, there is moderate scientific support (evidence level 3) for the use of proline-rich peptides in convalescence, but more research is needed to confirm efficacy and optimal dosing.