Nicotinamide, also known as niacinamide, is a form of vitamin B3. Its use in convalescence (the recovery period after illness or medical treatment) is primarily grounded in its essential role in cellular metabolism and energy production. Nicotinamide is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme central to redox reactions and cellular repair. During periods of illness or recovery, metabolic demands can increase, and deficiencies in B vitamins—including nicotinamide—may impede optimal recovery.

There is scientific rationale for supplementing nicotinamide during convalescence, especially in individuals at risk of deficiency due to malnutrition, chronic illness, or increased metabolic needs. Historical use and clinical observations support that replenishing B vitamins in such contexts can improve energy levels, appetite, and general well-being. However, direct clinical trials specifically evaluating nicotinamide supplementation in otherwise well-nourished individuals during convalescence are limited.

Most evidence supporting nicotinamide’s role is extrapolated from its well-established importance in preventing and treating pellagra (niacin deficiency) and its general requirement for tissue repair and immune function. Therefore, while the scientific basis for its use in deficiency states is clear, the evidence for routine use in convalescence without deficiency is moderate and mainly supportive, rather than robustly demonstrated in controlled trials.