Evidence supporting the use of: L-glycine
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine is a non-essential amino acid involved in numerous physiological processes, including protein synthesis, neurotransmission, and immune modulation. Its use during convalescence—the recovery period following illness or surgery—is based on its roles in tissue repair, immune function, and metabolic regulation. Scientific evidence suggests that glycine supplementation may support recovery by promoting collagen synthesis (important for wound healing), enhancing antioxidant defenses (by contributing to glutathione synthesis), and modulating inflammatory responses. Several animal studies have shown that glycine administration can improve healing and reduce tissue damage after injury or surgery, likely by reducing inflammation and oxidative stress.

However, direct clinical studies in humans specifically targeting the use of glycine for general convalescence are limited. Some studies have examined its benefits in specific contexts, such as wound healing or recovery from major trauma, with modest positive results. A few clinical trials have noted improved healing rates and reduced hospital stays in surgical patients receiving glycine-enriched formulas, but the evidence is not consistently robust or widespread. Overall, while there is plausible scientific rationale and some supportive preclinical and clinical evidence, the totality of data is not strong enough to unequivocally recommend glycine as a primary intervention for convalescence. Thus, its use can be considered scientifically plausible with limited evidence, meriting a rating of 2 out of 5.

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