Evidence supporting the use of: L-glutamine
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-glutamine is an amino acid that plays a crucial role in immune function, intestinal health, and the repair and maintenance of tissues, which is why it has been investigated for its potential to support convalescence (the period of recovery after illness or surgery). Scientific evidence suggests that during periods of severe physical stress—such as trauma, surgery, burns, or critical illness—glutamine levels in the body can become depleted. Supplementation in these contexts has been shown to help maintain gut barrier integrity, reduce infection rates, and support immune function.

Several clinical studies and meta-analyses have found that glutamine supplementation in hospitalized and critically ill patients may reduce complications, shorten hospital stays, and promote recovery. For example, glutamine has been added to parenteral nutrition regimens to improve outcomes in patients recovering from surgery or critical care. However, results are somewhat mixed, with some trials showing benefit and others not demonstrating significant effects, especially in well-nourished individuals or those with less severe illness.

Overall, while glutamine is not universally endorsed for all patients in convalescence, there is moderate scientific evidence supporting its use in specific populations where deficiency or high demand is likely. It is important for supplementation to be tailored to individual needs and clinical contexts, as routine use in all convalescent patients is not backed by strong, universal evidence.

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