Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Insulin-like Growth Factor (IGF), particularly IGF-1, is a peptide hormone with structural similarity to insulin and plays a major role in growth and anabolic processes, including muscle and tissue repair. The rationale for its use in convalescence—defined as the recovery period following illness or injury—is grounded in its physiological effects: IGF-1 stimulates protein synthesis, muscle regeneration, and cellular proliferation, all of which are relevant to tissue recovery. Several animal and human studies have demonstrated that exogenous IGF-1 administration can enhance muscle mass and accelerate recovery from catabolic states, such as severe illness or surgery.

Clinical trials in humans have shown mixed results. While some studies report improved nitrogen retention, muscle anabolism, and wound healing in patients with severe burns, trauma, or catabolic illnesses, others show limited benefit and raise concerns about side effects, including hypoglycemia and potential increased risk of malignancy. IGF-1 or IGF-1 analogs are not routinely used in standard convalescence protocols, but their use has been explored in specific populations (e.g., those with severe malnutrition or critical illness myopathy).

In summary, there is moderate scientific evidence (rated 3/5) that IGF-1 can support tissue repair and recovery during convalescence in certain clinical situations, but its use is not widespread due to safety concerns and inconsistent efficacy data. Its application is largely experimental and should be considered only in specialized settings under expert supervision.

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