Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hydrolyzed protein is frequently used in clinical nutrition, particularly for patients in convalescence—those recovering from illness, surgery, or trauma. Scientific evidence supports its use due to its rapid digestibility and enhanced absorption compared to intact proteins. Hydrolyzed proteins are proteins broken down into peptides and amino acids, which can be more readily absorbed, especially in individuals with compromised digestive capabilities—a common concern during convalescence. Clinical studies have shown that hydrolyzed protein supplementation can improve nitrogen balance, support muscle maintenance, and promote faster recovery by providing essential amino acids necessary for tissue repair and immune function. Medical nutrition products for post-surgical recovery and critical illness often utilize hydrolyzed proteins for these reasons. However, while multiple studies demonstrate improved protein utilization and tolerance, especially in patients with gastrointestinal dysfunction, there is some heterogeneity in outcomes related to broader recovery metrics (e.g., functional outcomes, length of stay). The overall evidence is moderate, with stronger support in specific populations (such as critically ill or malabsorptive patients) and less robust data in general convalescence. Thus, the use of hydrolyzed protein in convalescence is scientifically justified, but the strength of evidence is moderate rather than definitive.

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