Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fibroblast growth factor (FGF) is a family of growth factors involved in processes such as wound healing, tissue repair, and regeneration. There is scientific rationale for using FGFs to support convalescence, particularly due to their role in stimulating cell proliferation, angiogenesis, and tissue repair mechanisms. Preclinical studies and some early clinical research demonstrate that FGFs, especially basic FGF (bFGF or FGF-2), can accelerate wound healing and enhance recovery in models of tissue injury. They promote the proliferation of fibroblasts, endothelial cells, and other cell types crucial for repair, and have been investigated in settings such as skin ulcers, burns, and post-surgical recovery.

However, the direct use of FGF as a therapeutic agent in general convalescence (the recovery phase from illness or medical treatment) is not yet widely established in clinical practice. Most evidence comes from animal studies or small-scale human trials, often focusing on specific injuries rather than overall recovery. The regulatory approval for FGFs is limited to certain indications (e.g., topical use for specific ulcers in some countries). Systemic use for general convalescence lacks robust, large-scale clinical trial data. Thus, while the scientific basis is promising and there is some evidence for use in tissue-specific recovery, the overall evidence for supporting convalescence as a broad clinical indication is limited and not yet definitive.

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