Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dialyzable Leukocyte Extracts (DLEs) are low-molecular-weight fractions derived from human or animal leukocytes and are proposed to modulate immune responses. Their use in supporting or treating convalescence—particularly recovery after infections or illnesses—has some scientific rationale, albeit with limited and somewhat preliminary evidence. Clinical studies, primarily from Latin America, have explored DLEs in various contexts, including viral infections (such as herpes zoster), tuberculosis, and immune deficiencies. These studies suggest that DLEs may enhance immune recovery by transferring cell-mediated immunity, potentially shortening convalescence periods or reducing the risk of relapse. However, the majority of published studies are small, non-blinded, or lack rigorous controls, which limits the strength of the evidence.

Systematic reviews and meta-analyses are lacking, and major regulatory agencies have not approved DLEs for this indication. The theoretical basis for their use is the potential to enhance T-cell function and cytokine production, which could benefit patients recovering from illnesses with immune suppression or dysregulation. Still, the mechanism of action remains incompletely understood, and high-quality randomized controlled trials are scarce.

In summary, while there is some scientific investigation into the use of Dialyzable Leukocyte Extracts for convalescence, the evidence is limited to small-scale studies with modest outcomes. Thus, scientific support exists but is not robust, and further research is needed to clarify efficacy and safety.

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