Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Casein peptides are protein fragments derived from the enzymatic hydrolysis of casein, the primary protein found in milk. Their use in supporting convalescence (the recovery period after illness or surgery) is scientifically grounded, primarily due to their high nutritional value and bioavailability. During convalescence, the body's protein requirements are increased to support tissue repair, immune function, and the restoration of lean body mass. Casein peptides provide easily digestible and absorbable amino acids, which can help meet these increased demands, especially in individuals with impaired digestion or appetite. Clinical studies have demonstrated that casein-derived protein supplements can help maintain or improve muscle mass and function during recovery, particularly in elderly or malnourished patients. Additionally, casein peptides may exert immunomodulatory and antioxidant effects, which could further support the healing process. However, while animal and in vitro studies suggest additional benefits such as anti-inflammatory and gut barrier protective effects, robust clinical data directly linking casein peptides to improved outcomes in convalescent patients are limited. In summary, the use of casein peptides during convalescence is primarily based on their well-established nutritional role as a high-quality protein source, with some emerging evidence for additional bioactive effects. The strength of evidence is moderate (rated 3), reflecting good support for general protein supplementation but limited specific trials for casein peptides in convalescence.

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