Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-ketoglutarate (AKG) is a key intermediate in the Krebs (citric acid) cycle, essential for cellular energy production. Its use in supporting convalescence—recovery from illness, injury, or surgery—has some scientific rationale, primarily based on its role in amino acid metabolism and nitrogen balance. Research, particularly in clinical nutrition, suggests that AKG supplementation may help reduce muscle protein breakdown and support nitrogen retention, which are critical during periods of recovery when muscle wasting or catabolism can occur. Some studies have explored AKG as part of parenteral nutrition solutions, especially in hospitalized or post-surgical patients, with findings indicating mild benefits such as improved protein synthesis and reduced urea production, which may reflect improved nitrogen economy. However, the evidence is not robust. Clinical trials are limited in size and scope, and while some improvements in clinical or biochemical parameters have been observed, consistent and significant benefits in functional recovery or clinical outcomes are not well established. Most guidelines do not specifically recommend AKG for convalescence outside of specialized nutrition support contexts. Thus, while there is a scientific basis and some supporting evidence, its use remains adjunctive rather than standard, and the overall quality of evidence is modest (rated 2 out of 5).

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