Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata, a plant widely used in traditional medicine systems, particularly in Ayurveda and Traditional Chinese Medicine (TCM). In these traditions, extracts of Andrographis paniculata—rather than isolated neoandrographolide—have been used for centuries to manage symptoms of a range of infectious diseases, such as colds, influenza, and other respiratory infections. The historical use is mostly attributed to the plant’s purported "immune-strengthening" and "heat-clearing" properties.

While modern scientific studies have explored the antibacterial, antiviral, and immunomodulatory properties of Andrographis paniculata extracts, the bulk of research focuses on andrographolide, another major compound, rather than neoandrographolide specifically. There is limited but emerging evidence for the immunomodulatory effects of neoandrographolide, and a few in vitro studies suggest it may have antiviral or anti-inflammatory activity. However, robust clinical evidence—especially trials in humans using the purified compound for contagious diseases—is lacking.

Overall, the use of neoandrographolide for contagious diseases is primarily justified by traditional use of the plant. Scientific validation, especially for neoandrographolide alone, remains limited, and most supportive evidence is extrapolated from studies of the whole plant or other related compounds.

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