Evidence supporting the use of: Sorbitol ester
For the health condition: Constipation (children)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Sorbitol esters, most notably sorbitol itself, have a well-established role in the management of constipation, including in pediatric populations. Sorbitol is a sugar alcohol with osmotic laxative properties—it is poorly absorbed in the gut, drawing water into the colon and stimulating bowel movements. While "sorbitol ester" can refer to a range of compounds, the most clinically relevant is sorbitol or sorbitan-based derivatives used as osmotic agents.
Numerous clinical studies and guidelines support the use of sorbitol as a safe and effective laxative in children with constipation. For example, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) includes sorbitol as a recommended osmotic laxative for pediatric constipation. Studies have shown that oral or rectal administration of sorbitol increases stool frequency and improves stool consistency in children with functional constipation, with efficacy comparable to other agents like lactulose.
Sorbitol’s use in this context is thus grounded in scientific evidence, with systematic reviews and clinical experience supporting its safety when used at appropriate doses. However, its use should be monitored, as excessive intake may lead to diarrhea or abdominal discomfort. In summary, sorbitol (and its esters when used for this purpose) is an evidence-based treatment for pediatric constipation, with a strong safety and efficacy profile documented in the medical literature.
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