Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Aloe, specifically Aloe vera latex (the yellowish substance derived from the inner leaf skin), has been traditionally used as a laxative to support or treat constipation. The primary active compounds responsible for its laxative effect are anthraquinone glycosides, mainly aloin. These compounds stimulate peristalsis (the contraction of intestinal muscles), increase intestinal water content, and promote bowel movements. Several clinical studies have examined the efficacy of Aloe latex for constipation. A few randomized controlled trials from the late 20th and early 21st centuries have shown that Aloe latex can be more effective than placebo in increasing stool frequency and softening stools in adults with constipation. However, most of these studies are small, short-term, and sometimes methodologically limited.

Major health agencies, such as the U.S. Food and Drug Administration (FDA), have raised concerns about safety: in 2002, the FDA required manufacturers to remove Aloe-containing over-the-counter laxatives from the market due to insufficient data on safety. Chronic use of Aloe latex may cause abdominal cramps, electrolyte imbalance, and, rarely, kidney issues. Additionally, Aloe gel (the clear inner pulp) does not have the same laxative effect as the latex and is not used for constipation.

In summary, there is moderate scientific evidence, largely based on the physiological action of anthraquinones and some clinical trials, to support the short-term use of Aloe latex for adult constipation. However, concerns about safety and lack of robust long-term studies limit its clinical recommendation.

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