Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Neem (Azadirachta indica) has a long history of use in traditional medicine systems, particularly in Ayurveda and folk remedies across South Asia. For conjunctivitis, neem leaves, twigs, and extracts have been used topically and as eyewashes to reduce inflammation and combat infection. The justification for this practice primarily comes from traditional knowledge, which attributes neem with broad antimicrobial, anti-inflammatory, and soothing properties. Neem contains compounds such as nimbidin, nimbin, and azadirachtin that have demonstrated antibacterial and antiviral activity in laboratory settings. However, there is limited direct clinical evidence specifically validating the use of neem for conjunctivitis in humans. Most supporting literature consists of in vitro studies or animal models showing neem's general antimicrobial and anti-inflammatory effects. Historical texts and ethnobotanical surveys report neem’s use in treating eye infections, but these accounts lack modern controlled clinical trials to confirm efficacy and safety for conjunctivitis in particular. In summary, while neem’s use for conjunctivitis is well-rooted in tradition and has some plausible biological basis, robust scientific evidence is lacking, and thus it is typically rated as having low to moderate support on the evidence scale.

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