Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids are a class of polyphenolic compounds found in various fruits, vegetables, and medicinal plants. They are well-studied for their antioxidant, anti-inflammatory, and antimicrobial properties. Regarding conjunctivitis (commonly known as "pink eye"), scientific interest has focused on the potential of flavonoids to reduce inflammation and inhibit pathogens that can cause or exacerbate ocular surface diseases. Several in vitro and animal studies suggest that certain flavonoids, such as quercetin and luteolin, can inhibit the release of pro-inflammatory cytokines and stabilize mast cells, potentially reducing allergic and inflammatory responses in the eye. Some studies have also demonstrated antimicrobial effects against pathogens commonly implicated in conjunctivitis, such as Staphylococcus aureus and Escherichia coli.

However, rigorous clinical trials in humans specifically assessing flavonoid supplementation or topical application for conjunctivitis are sparse. The majority of evidence comes from laboratory research or broader studies on ocular inflammation rather than conjunctivitis per se. As such, while the mechanistic rationale is plausible and there is some preclinical support, direct clinical validation is limited. Thus, the current evidence rating is 2 out of 5, indicating preliminary support but insufficient high-quality clinical data to firmly establish efficacy for conjunctivitis.

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