Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astragalin is a naturally occurring flavonoid (kaempferol-3-O-glucoside) found in various medicinal plants such as Persicaria chinensis and Astragalus membranaceus. There is some preliminary scientific evidence supporting its use for conjunctivitis, primarily from in vitro and animal studies. Research has shown that astragalin possesses anti-inflammatory, antioxidant, and anti-allergic properties. Notably, a study published in International Immunopharmacology (2013) demonstrated that astragalin could inhibit the production of pro-inflammatory cytokines in a mouse model of allergic conjunctivitis, resulting in reduced clinical symptoms. Another study reported that astragalin suppressed mast cell activation and histamine release, key factors in allergic eye inflammation.

Despite these promising findings, the majority of the evidence is preclinical, and there are no robust clinical trials in humans specifically evaluating astragalin for conjunctivitis. Its use is not widely established in traditional medicine specifically for conjunctivitis, but rather as part of broader anti-inflammatory herbal remedies. Therefore, while there is a scientific rationale and some experimental support for astragalin’s potential benefits in conjunctivitis, the overall evidence is still limited, and further research, especially well-designed human clinical trials, is necessary to confirm its efficacy and safety for this indication.

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