Evidence supporting the use of: Vitamin D
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has been investigated as a supportive treatment for congestive heart failure (CHF) due to its role in cardiovascular and immune health. Several observational studies have found that vitamin D deficiency is common in patients with CHF and is associated with worse clinical outcomes, including increased mortality and hospitalization rates. Mechanistically, vitamin D may influence heart function through modulation of the renin-angiotensin-aldosterone system, reduction of inflammation, and improvement of endothelial function. Interventional studies and randomized controlled trials (RCTs), however, have yielded mixed results. Some small RCTs have shown that vitamin D supplementation can improve cardiac function (e.g., left ventricular ejection fraction) and reduce inflammatory markers in CHF patients, while others have found no significant benefit on hard clinical endpoints such as mortality or hospitalization.

A 2019 meta-analysis in Heart Failure Reviews concluded that while supplementation may improve surrogate endpoints like ejection fraction, there is insufficient evidence to recommend routine vitamin D supplementation for all CHF patients due to a lack of consistent benefit on major clinical outcomes. Current heart failure guidelines do not recommend vitamin D supplementation solely for CHF unless there is proven deficiency. In summary, although there is some scientific rationale and preliminary evidence suggesting benefit, the overall strength and consistency of the evidence is low to moderate, and routine use is not yet justified outside of correcting deficiency.

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Other health conditions supported by vitamin D

Acne
Allergies (food)
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Alzheimer's Disease
Amenorrhea
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Anorexia
Apathy
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Concentration (poor)
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Congestive Heart Failure
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Crohn's Disease
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Dandruff
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Erectile Dysfunction
Estrogen (low)
Fatigue
Fibroids (uterine)
Fibromyalgia Syndrome
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Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
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Hypertension
Hypothyroid
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Infertility
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Inflammatory Bowel Disorders
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