Evidence supporting the use of: Resveratrol
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol is a polyphenolic compound found in foods like grapes, red wine, and certain berries. Its use in supporting or treating congestive heart failure (CHF) is based on emerging scientific evidence, but not on traditional medical practices or long-standing usage. Experimental studies have shown that resveratrol has antioxidant, anti-inflammatory, and cardioprotective properties. In preclinical models, resveratrol has been demonstrated to improve cardiac function, reduce myocardial fibrosis, and enhance endothelial function—factors relevant in CHF pathophysiology. Some small-scale clinical trials and pilot studies in humans suggest resveratrol supplementation may improve endothelial function, reduce inflammation, and potentially enhance cardiac output or exercise capacity in heart failure patients. However, these studies often involve small sample sizes, short durations, and variable dosing, limiting the reliability and generalizability of their findings.

There is not yet robust, large-scale clinical trial evidence confirming a significant benefit of resveratrol in CHF patients. Therefore, while there is scientific rationale and preliminary evidence supporting possible benefits, resveratrol should not be considered a standard or proven treatment for congestive heart failure. More high-quality clinical research is needed to determine its efficacy and safety for this indication.

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