Evidence supporting the use of: Arginine
For the health condition: Congestive Heart Failure
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Arginine (L-arginine) is an amino acid that serves as a precursor to nitric oxide, a molecule involved in vasodilation and endothelial function. The rationale for its use in congestive heart failure (CHF) stems from evidence that nitric oxide production is impaired in heart failure, and supplementation might improve vascular tone and cardiac function. Several small clinical studies and pilot trials have explored L-arginine supplementation in CHF patients, with mixed results. Some studies reported improvements in exercise capacity and hemodynamic parameters, attributing these effects to enhanced nitric oxide-mediated vasodilation. However, other trials have not demonstrated significant benefits, and concerns have been raised about the safety and efficacy of chronic arginine supplementation in this population. A notable randomized controlled trial (the VINTAGE MI study, though in post-MI patients) even suggested possible harm. Major cardiology guidelines do not recommend arginine supplementation in CHF due to insufficient high-quality evidence. In summary, while there is a plausible scientific rationale and limited supportive data from early-phase studies, the overall quality and consistency of evidence are low. Arginine is not widely used or recommended as a standard therapy for CHF.
Other ingredients used for Congestive Heart Failure
adenosine 5-triphosphate disodium (ATP)algal oil
arjun tree
astragalus
black garlic
coenzyme Q10 (CoQ10)
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish oil
flavonols
garlic bulb
ginseng
hawthorn
l-arginine
l-carnitine
l-citrulline
l-taurine
marine lipid
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
ophiopogon root
potassium
resveratrol
thiamin (vitamin B1)
ubiquinol
vitamin D
zinc
β-nicotinamide mononucleotide (NMN)
AMP-activated protein kinase (AMPK)
Arjuna
Allicin
Arginine orotate
Astragaloside
Arjunic Acid
Black Seed
Chinese Silkvine
Catecholamine
Cowherb
Docosahexaenoic Acid
Danshen
Digitalis
Eicosapentaenoic Acid
Foxglove
Fatty acids
Flavanols
Glycoside
Theophylline
Other health conditions supported by Arginine
AnginaAthletic and Exercise Aids
Body Building
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Circulation (poor)
Congestive Heart Failure
Diabetes
Erectile Dysfunction
Fatigue
Heart (weakness)
Hypertension
Infertility
Peripheral Neuropathy
Sex Drive (low)
Testosterone (low)
Thrombosis
Wounds and Sores