Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vasicinone is an alkaloid isolated from the plant Adhatoda vasica (also known as Malabar nut), which has a long history in traditional medicine systems such as Ayurveda for the treatment of respiratory ailments, including congestion. Scientific studies have provided some support for its use: vasicinone, along with its related compound vasicine, has been shown in preclinical studies to possess bronchodilatory and expectorant properties. These actions are thought to help relieve bronchial congestion by relaxing the bronchial muscles and facilitating the expulsion of mucus from the respiratory tract.

For example, research published in the Indian Journal of Pharmacology and other pharmacological studies have demonstrated that vasicinone can have a moderate bronchodilator effect in animal models. It may also stimulate the ciliary movement of the respiratory tract, thereby aiding in mucus clearance. However, while these pharmacological properties are promising, most of the evidence comes from laboratory and animal studies. There is a scarcity of robust clinical trials in humans to confirm its efficacy and safety for treating congestion specifically. Therefore, while there is a scientific rationale and some supporting preclinical data for the use of vasicinone in congestion, the overall strength of evidence remains limited (rated 2/5), and further human studies are needed to substantiate its clinical use.

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Other ingredients used for Congestion

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