Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyritinol, also known as pyridoxine disulfide, is a semi-synthetic derivative of vitamin B6 and has been used in several countries as a cognitive enhancer and in the treatment of cognitive deficits, including poor concentration. The scientific evidence to support its use for improving concentration is limited but does exist. Some double-blind, placebo-controlled studies from the 1970s and 1980s investigated pyritinol in populations with age-associated cognitive impairment, traumatic brain injury, or mild to moderate dementia. These studies occasionally reported modest improvements in cognitive performance, including attention and concentration, though the clinical significance was often questioned due to small sample sizes and methodological limitations.

For example, a few trials in elderly patients with cognitive deficits suggested that pyritinol might improve attention and psychomotor speed. However, most research has not been replicated in recent decades, and high-quality, large-scale studies are lacking. Systematic reviews and meta-analyses have generally concluded that while pyritinol is relatively safe, the evidence supporting its efficacy in improving concentration is weak and inconsistent. Thus, while its use is justified by some scientific validation, the overall quality and quantity of evidence is low, resulting in a modest score of 2 out of 5 for supporting this indication.

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