Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a cholinergic compound that serves as a precursor to acetylcholine, an important neurotransmitter involved in memory, learning, and attention. Scientific interest in Alpha-GPC has focused on its potential to support cognitive functions, including concentration, particularly in populations with cognitive decline. Several randomized controlled trials and clinical studies have investigated Alpha-GPC's effects on cognitive performance. For example, research in elderly patients with mild to moderate dementia has demonstrated that Alpha-GPC supplementation can improve certain aspects of cognitive function, including attention and memory. One double-blind, placebo-controlled study found that daily administration of Alpha-GPC led to significant improvements in attention and cognition compared to placebo.

However, evidence in healthy adults or those suffering solely from poor concentration (without underlying neurodegenerative disease) is more limited. Some small studies suggest potential benefits for mental performance, but findings are not always consistent, and more robust, large-scale trials are needed. The mechanism is believed to be related to increased acetylcholine availability in the brain, which is crucial for attentional processes. Alpha-GPC is generally regarded as safe and well-tolerated, but its effectiveness as a standalone supplement for improving concentration in otherwise healthy individuals remains only moderately supported by the scientific literature.