Evidence supporting the use of: Sennosides
For the health condition: Colon (atonic)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Sennosides are stimulant laxatives derived from the senna plant and are primarily used for the treatment of constipation, including cases associated with atonic colon (a condition where the colon loses muscle tone and becomes less able to move stool). The scientific justification for their use is well established. Sennosides work by irritating the lining of the colon, which stimulates peristalsis (the muscular contractions that push stool through the colon). This is particularly helpful in atonic colon, where natural peristalsis is reduced.
Multiple randomized controlled trials and meta-analyses have demonstrated the efficacy of sennosides in increasing bowel movement frequency and improving stool consistency in patients with chronic constipation, including those with atonic features. Sennosides are commonly included in clinical guidelines for the management of opioid-induced constipation and other forms of chronic constipation.
However, long-term use is cautioned due to the potential for dependency and worsening of colonic atony. The evidence base supporting their short-term use is strong (hence the rating of 4/5), but concerns about adverse effects and lack of studies on long-term outcomes prevent a higher evidence score. In summary, sennosides are scientifically validated for short-term symptomatic relief of constipation in atonic colon, but should be used judiciously.
Other health conditions supported by Sennosides
Colon (atonic)Constipation (adults)
Constipation (children)
