Evidence supporting the use of: Hydroxyanthracene
For the health condition: Colon (atonic)
Synopsis
Source of validity: Traditional
Rating (out of 5): 3
Hydroxyanthracene derivatives, such as those found in senna, cascara, and aloe species, have a long history of traditional use as stimulant laxatives to treat atonic (hypotonic or sluggish) colon and constipation. Their use dates back thousands of years, particularly in traditional herbal medicine systems such as Ayurveda and traditional European herbal practice. The mechanism of action involves stimulation of colonic peristalsis by direct effects on the intestinal mucosa and increased secretion of water and electrolytes into the bowel. While there is modern scientific evidence supporting their short-term efficacy as laxatives, the use for specifically "atonic colon" is rooted more in traditional concepts of bowel sluggishness, which corresponds to what is now termed chronic constipation or slow-transit constipation.
Clinical studies and pharmacopoeias (such as the European Medicines Agency monographs) acknowledge hydroxyanthracene-containing preparations as effective for short-term relief of occasional constipation. However, the evidence for long-term use or for specifically reversing atonia of the colon is limited; concerns over potential side effects, such as electrolyte imbalances and possible mucosal damage with prolonged use, have been raised. Thus, while the traditional use is strong and some modern evidence supports their general laxative effect, the specific use for "atonic colon" is mainly justified by tradition with moderate scientific backing for constipation relief in general.
Other health conditions supported by Hydroxyanthracene
Colon (atonic)Colon (spastic)
Constipation (adults)
Constipation (children)
