Bulking agents, also known as bulk-forming laxatives (e.g., psyllium, methylcellulose, polycarbophil), are widely used in the management of atonic colon, a condition characterized by reduced colonic muscle tone and consequent impaired peristalsis. Their use is strongly supported by scientific evidence and is recommended by major clinical guidelines for treating chronic constipation and conditions with colonic hypomotility. Bulking agents work by absorbing water and increasing stool mass, thereby stimulating colonic stretch receptors and promoting peristaltic activity. Several randomized controlled trials and systematic reviews have demonstrated that bulk-forming laxatives improve stool frequency and consistency in patients with chronic constipation, including those with atonic colon. The American Gastroenterological Association and other expert bodies include bulking agents as first-line therapy for constipation due to their efficacy and favorable safety profile. However, their effectiveness depends on adequate fluid intake, and they may be less effective in cases of severe colonic inertia. Adverse effects are generally mild, including bloating or flatulence. In summary, bulking agents have a robust evidence base supporting their use in atonic colon and remain a cornerstone in the conservative management of this condition.