Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sophora flavescens (also known as Ku Shen) is a traditional Chinese medicinal herb that has been investigated for its potential therapeutic effects in colitis, particularly ulcerative colitis and other inflammatory bowel diseases (IBD). The scientific evidence supporting its use comes primarily from preclinical studies, including in vitro and animal models. Compounds isolated from Sophora flavescens, such as matrine and oxymatrine, have demonstrated anti-inflammatory, immunomodulatory, and antioxidant properties. Several studies have shown that extracts of this herb can reduce colonic inflammation, decrease pro-inflammatory cytokine production (e.g., TNF-α, IL-6), and improve histological outcomes in chemically-induced colitis models in mice and rats.

Despite promising preclinical results, high-quality human clinical trials are lacking. There are a few small clinical studies from China suggesting potential benefit as an adjunct to conventional therapy, but these studies are limited by small sample sizes and methodological weaknesses. As a result, while there is a scientific rationale and supportive laboratory evidence for the use of Sophora flavescens in colitis, the overall quality and quantity of clinical evidence remain insufficient. Thus, its use for colitis is rated as 2 out of 5 for evidence, indicating preliminary scientific support but not enough for widespread clinical recommendation.

More about Sophora flavescens
More about Colitis

Other ingredients used for Colitis

Other health conditions supported by Sophora flavescens

Products containing Sophora flavescens