Synopsis

Source of validity: Scientific
Rating (out of 5): 2

There is some scientific evidence supporting the use of certain organic acids, particularly short-chain fatty acids (SCFAs) like butyrate, in the management of colitis. SCFAs are produced naturally in the colon by bacterial fermentation of dietary fibers and have been shown to play a critical role in maintaining gut health. Butyrate, in particular, serves as an energy source for colonic epithelial cells and has anti-inflammatory properties. Several clinical studies and animal models of colitis (including ulcerative colitis) have demonstrated that butyrate enemas or supplements can reduce inflammation, promote mucosal healing, and improve symptoms in some patients. However, the overall quality and quantity of clinical evidence are still limited, with most studies being small, short-term, and sometimes lacking rigorous controls. Other organic acids, such as acetic and propionic acid, are less studied but may contribute to gut health via similar mechanisms. To date, the therapeutic use of organic acids for colitis is not a standard treatment and is best considered experimental or adjunctive. Thus, while there is a mechanistic rationale and early clinical evidence, large-scale, high-quality trials are needed to firmly establish efficacy and safety for colitis treatment.

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