Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus rhamnosus, particularly the GG strain (L. rhamnosus GG), has been studied for its potential benefits in various gastrointestinal disorders, including different forms of colitis such as ulcerative colitis and pouchitis. The scientific rationale is based on its ability to modulate gut microbiota, enhance mucosal barrier function, and exert anti-inflammatory effects. Several randomized controlled trials and meta-analyses have evaluated the efficacy of L. rhamnosus GG as an adjunctive therapy in inflammatory bowel diseases (IBD).

For ulcerative colitis, evidence suggests that L. rhamnosus GG may help maintain remission, especially when used alongside standard treatments like mesalamine. However, results are mixed, with some studies showing benefit in reducing relapse rates and others demonstrating minimal or no effect. In pouchitis (inflammation of the ileal pouch after surgical removal of the colon), L. rhamnosus GG has shown more consistent benefit, particularly in preventing onset or recurrence when used prophylactically.

The overall evidence is moderate (rated 3/5). L. rhamnosus GG is generally recognized as safe, and its use is supported by clinical guidelines as an adjunct in some cases, particularly for pouchitis. However, it is not universally effective for all patients with colitis, and results can vary depending on the specific type and severity of the condition. More robust, large-scale studies are needed to fully clarify its therapeutic role in colitis.

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