Evidence supporting the use of: Lactobacillus paracasei
For the health condition: Colitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus paracasei has been investigated as a probiotic for supporting or treating colitis, particularly in preclinical studies and several small human trials. The rationale for its use is based on the understanding that colitis, including ulcerative colitis and other forms of inflammatory bowel disease (IBD), is associated with dysbiosis (an imbalance in gut microbiota) and inflammation of the colon. L. paracasei is thought to exert beneficial effects by modulating the immune response, enhancing the intestinal barrier, and inhibiting the growth of pathogenic bacteria.

Animal studies have shown that administration of L. paracasei can reduce colonic inflammation, decrease pro-inflammatory cytokines, and improve histological scores in models of chemically induced colitis. In humans, the evidence is less robust but suggestive: a few small clinical trials and pilot studies, sometimes using L. paracasei alone or in combination with other probiotics, have reported improvements in symptoms, reduced disease activity, and enhanced mucosal healing. For instance, a 2019 randomized controlled trial found that a probiotic mixture containing L. paracasei led to symptomatic relief in ulcerative colitis patients, though isolating the effect of this single strain remains challenging.

Overall, while there is scientific rationale and emerging evidence supporting the use of L. paracasei for colitis, the current clinical evidence is limited and not yet conclusive. More large-scale, well-designed human trials are needed to firmly establish efficacy and recommend routine use.

More about lactobacillus paracasei
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Other ingredients used for Colitis

akkermansia muciniphila
algal oil
aloe vera
anthocyanins
apple
astaxanthin
bacillus clausii
bacillus coagulans
bacillus subtilis
barberry
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
bilberry
bio ecolian (proprietary)
blueberry
bromelain
butyrate triglyceride
cat's claw
Chinese salvia root
chlorella
Coptis chinensis
cowage seed
turmeric
curcumin
fiber blend (proprietary)
flavonols
garlic bulb
ginger
green tea
hemp oil
immunoglobin G
inulin
isomalto-oligosaccharide
l-glutamine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus casei
lactobacillus fermentum
lactobacillus gasseri
lactobacillus lactis
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
lactoferrin
licorice root
n-acetyl-cysteine (NAC)
plantain
pomegranate
prebiotic blend (proprietary)
butyric acid
quercetin
resveratrol
saccharomyces boulardii
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
triphala
zinc
xanthium (cockleburs)
blackboard tree
picrorhiza kurroa
swertia
buckthorn
anemarrhena asphodeloides
algae
Apple Cider Vinegar
Apigenin
Anamu
Alchornea
Andrographolide
Asteracea
Acemannan
Amor seco
Astragalin
Bifidobacterium
Bifidobacterium adolescentis
Boswellic Acid
Bael
Basidiomycota
Boswellia
Baccharoides anthelmintica
Bifidobacterium animalis
Black Nightshade
Bacteria
Bifidobacteria
Bacillus
Cactus
Curcuminoid
Curcumen
Curcuma
Cabbage
Clostridium butyricum
Colocynth
Diterpenes
Euphorbia
Fucoidan
Fiber
Frangula
Gallic Acid
Glycomacropeptides
Glycyrrhetinic Acid

Products containing lactobacillus paracasei