Chinese Tinospora (Tinospora sinensis or Tinospora cordifolia, commonly called Guduchi in traditional medicine) has a historical record of use in Traditional Chinese Medicine (TCM) and Ayurveda for treating various inflammatory disorders, including conditions that could correspond to colitis (such as chronic diarrhea, dysentery, and intestinal inflammation). Its use is primarily justified by traditional knowledge, where it is described as having properties to "clear heat," "remove toxins," and support gastrointestinal health.

Modern scientific research on Tinospora's efficacy specifically for colitis is limited. Some in vitro and animal studies suggest immunomodulatory and anti-inflammatory effects, with a few rodent models showing attenuation of chemically-induced colitis symptoms when treated with Tinospora extracts. For example, studies in mice have reported reductions in colonic inflammation, oxidative stress, and cytokine levels. However, these results are preliminary, and there is a lack of robust human clinical trials validating its safety and effectiveness for colitis or inflammatory bowel disease in humans.

Therefore, while traditional sources support its use for intestinal inflammation, and there is early-stage preclinical evidence suggesting potential benefit, the overall quality and quantity of scientific evidence are insufficient for strong recommendations. Its use for colitis remains primarily traditional, with moderate support from animal research but not from clinical trials.