Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Holarrhena, particularly Holarrhena antidysenterica, has a long history of use in traditional medicine systems such as Ayurveda and Unani. Traditionally, its bark and seeds have been employed to address a range of gastrointestinal issues, including diarrhea, dysentery, and colic. The rationale for its use in colic (abdominal pain often associated with gastrointestinal disturbance) is primarily based on its reputed antispasmodic, astringent, and anti-inflammatory properties as described in classical texts and ethnobotanical reports. However, the majority of available scientific studies focus on its efficacy in treating infectious diarrhea and dysentery, rather than directly on colic in adults. There is some limited experimental evidence in animal models supporting antispasmodic and gut-modulatory activity, but these findings have not been robustly translated to clinical trials in humans specifically for colic. Thus, while Holarrhena is historically used for gastrointestinal discomfort, including colic, there is a lack of high-quality clinical evidence directly validating this indication. Its ongoing use for colic is mainly justified by traditional practice rather than by scientific validation.

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