Botanical blends have a long history of use in traditional medicine systems across various cultures for the management of colds, especially those accompanied by fever. Traditionally, these blends often contain herbs such as elderberry, echinacea, ginger, yarrow, and peppermint, among others. These ingredients have been used in folk remedies to reduce fever, promote sweating, alleviate congestion, and provide symptomatic relief. For example, yarrow has been used in European herbalism as a diaphoretic (inducing sweating) to help lower fevers. Elderberry and echinacea are popular in both Native American and European traditions for their supposed ability to support the immune system during colds. Ginger and peppermint have been employed to ease respiratory discomfort and provide mild anti-inflammatory effects. However, while these uses are well-documented in historical texts and ethnobotanical surveys, robust clinical evidence supporting the efficacy of most botanical blends for treating colds with fever remains limited. Some individual components (like elderberry) have modest supporting data, but the overall effectiveness and safety of multi-herb botanical blends have not been thoroughly validated in large, high-quality clinical trials. Therefore, while the use of botanical blends for colds with fever is justified by tradition, the scientific evidence remains preliminary or anecdotal.