Softgel (or soft gel) capsules are not an active ingredient themselves but rather a dosage form commonly used to deliver various active compounds, including decongestants used for the relief of cold symptoms. Many over-the-counter cold medications, particularly those containing decongestants like pseudoephedrine or phenylephrine, are formulated in softgel capsules for several practical reasons. Softgels can encapsulate liquid or oil-based formulations, often allowing for quicker absorption than traditional tablets. This can result in faster onset of action, which is desirable in acute symptom management such as nasal congestion during colds.

The use of softgel formulations for decongestant delivery is supported by pharmaceutical research indicating improved bioavailability and patient compliance due to easier swallowing and reduced gastrointestinal irritation compared to some tablet forms. However, the clinical efficacy of the softgel itself is not the focus; rather, it is the active ingredient inside (e.g., pseudoephedrine) that has a well-established role in the symptomatic relief of nasal congestion based on randomized controlled trials and meta-analyses. The softgel serves as an effective delivery vehicle, and its use is justified by scientific and practical considerations in drug formulation, but it is not the source of therapeutic action.

In summary, softgels are scientifically validated as a delivery method for decongestants used in cold treatment, but the therapeutic effect is due to the encapsulated drug, not the softgel itself.