Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Allyl isothiocyanate (AITC), the compound responsible for the pungent flavor of mustard, horseradish, and wasabi, has a long history of use in traditional remedies for respiratory complaints such as colds and congestion. Traditional herbal medicine systems, particularly in Europe and East Asia, have employed preparations from plants containing AITC as topical rubefacients or in food to "clear the sinuses." The characteristic pungency of AITC is known to stimulate the trigeminal nerve endings in the nasal mucosa, producing a sensation of nasal clearing or decongestion. However, there is limited clinical research directly assessing the efficacy of AITC as a decongestant or cold remedy. Most available evidence is anecdotal or based on the sensory effects observed upon ingestion or inhalation, such as a temporary increase in nasal airflow due to irritation-induced mucus thinning. There are no high-quality randomized controlled trials confirming objective clinical benefits for cold symptoms. Therefore, while the traditional use of AITC-containing preparations for colds and congestion is well documented, scientific validation for these effects remains minimal and the evidence should be considered weak.

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