Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Moisture is commonly recommended for the symptomatic relief of cold sores (herpes labialis). The use of moisturizers, such as lip balms or ointments (often containing petrolatum, beeswax, or other emollients), is primarily to prevent the affected area from drying, cracking, and becoming more painful or susceptible to secondary infection. Scientific validation comes from studies and clinical guidelines that acknowledge the role of supportive care, including maintaining moisture, to improve comfort and potentially accelerate healing by protecting the lesion and facilitating the skin’s repair process. However, moisturizers do not have antiviral effects and do not directly treat the underlying herpes simplex virus infection. Instead, their benefit is adjunctive—helping to reduce discomfort, minimize fissuring and bleeding, and possibly reduce the risk of bacterial superinfection. Major dermatology and infectious disease guidelines (e.g., American Academy of Dermatology) support the use of moisturizers as part of symptomatic management. While the level of evidence is moderate (hence the score of 3), and not based on large randomized controlled trials, the consensus among clinicians and the physiologic rationale for barrier protection justify their use in practice. In summary, moisturizing agents are scientifically validated for symptomatic relief, but not for antiviral activity or as a primary treatment for the infection itself.

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