Evidence supporting the use of: Glycyrrhizinic acid
For the health condition: Cold Sores

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycyrrhizinic acid, also known as glycyrrhizin, is a compound derived from licorice root (Glycyrrhiza glabra). Its use for cold sores (herpes labialis) is primarily supported by laboratory and some clinical evidence showing antiviral activity, particularly against the herpes simplex virus (HSV). Glycyrrhizin has been shown in in vitro studies to inhibit the replication of HSV-1, the virus responsible for most cold sores, by interfering with viral gene expression and replication. Additionally, it may modulate immune responses, reducing inflammation associated with outbreaks.

There are limited clinical studies evaluating topical or oral glycyrrhizinic acid specifically for cold sores in humans. Some small-scale clinical trials and case reports suggest potential benefits, with topical formulations reducing the frequency or severity of outbreaks. However, these studies are generally of low methodological quality, with small sample sizes and lack of standardization in formulation and dosing. As such, while there is a biochemical and mechanistic rationale for its use, and preliminary data suggest possible efficacy, robust clinical evidence is lacking.

In summary, glycyrrhizinic acid's use for cold sores is supported by preclinical antiviral data and some suggestive, though not conclusive, clinical evidence. More rigorous and larger-scale clinical trials are needed to firmly establish its safety and efficacy for this indication.

More about Glycyrrhizinic acid
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Products containing Glycyrrhizinic acid

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