Evidence supporting the use of: Resveratrol
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol is a polyphenolic compound found in grapes, red wine, and several other plants. Its use in supporting or treating cirrhosis of the liver is based primarily on emerging scientific research rather than traditional medicine. Preclinical studies, mainly in animal models and cell cultures, suggest that resveratrol may have hepatoprotective effects. These effects are thought to be related to its antioxidant, anti-inflammatory, and anti-fibrotic properties. For example, resveratrol has been shown to reduce oxidative stress, inhibit the activation of hepatic stellate cells (which play a central role in the development of liver fibrosis), and modulate signaling pathways associated with liver injury and regeneration.

However, clinical evidence in humans with cirrhosis is limited. Most studies evaluating resveratrol’s effects on liver health are small, short-term, or focus on earlier stages of liver disease (such as non-alcoholic fatty liver disease, NAFLD) rather than established cirrhosis. There are currently no large-scale, high-quality randomized controlled trials demonstrating clear benefits of resveratrol supplementation in patients with cirrhosis. As such, while the mechanistic rationale and preclinical evidence are promising, the current level of evidence supporting its use for cirrhosis in humans is modest (rated 2/5).

In summary, resveratrol is not a standard or widely accepted treatment for cirrhosis, but it is being investigated for its potential liver-protective effects. More robust human studies are needed before it can be recommended for this purpose.

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